Decoding Neurological Disorders

Decoding Neurological Disorders

A neurological disorder is basically any kind of disorder within the nervous system caused by structural, biochemical or electrical abnormalities through the brain, spinal cord or other nerves. It can result in a variety of symptoms that go from paralysis, muscle weakness and poor coordination to confusion or seizures.

Methods to prevent neurological disorders involve lifestyle changes, therapies and medication; sometimes it goes to the point of operations performed by a neurosurgeon. However, any of these measures will require a previous neural decoding.

Neural Decoding

This is a neuroscience concerned with the reconstruction of sensory and other stimuli from information that has already been encoded in the brain’s networks, referring to the ability to predict what sensory stimuli the subject is receiving based purely on action potentials. The final goal is to figure out how the electrical activities of neurons will response inside the brain. This means the process of decoding a neurological disorder goes all about finding out what different kind of stimulations will cause the brain or body to react in an abnormal way.  Here a closer look at neural decoding.

Neurological symptoms that might lead to disorders and must not be ignored go from weakness, blurry vision and dizziness; to headaches, difficulty to put thoughts together, and shock like pains in different parts of the body. Any of these symptoms should be the green light to go to a neurologist as soon as possible.

Whole-Genome Sequencing

The Whole Genome DNA sequencing has been used to decode the Charcot Marie Tooth neuropathy. It involves the sequencing of a pro-band affected by the disease, identifying all SNPs and CNVs across the genome, by focusing in any coding variant known to affect the nerve conduction. This process led to the identification of 2 proteins changing SNPs present in the SH3TC2 gene, a candidate gene that was previously associated with the Charcot Marie Tooth disease. This situation made clear the effectiveness of the whole genome sequencing to identify small variants with modest effects that might make one susceptible to any kind of neurological disease. The prices of a DNA Sequencing in free fall are also an encouragement to use the whole genome sequencing to define the genetic causes of several common heritable diseases.

Other treatments for neurological disorders

  • Brain mapping: A 3 dimensional image of the brain that allows surgeons to accurately target any dissection to the smallest degree.
  • Cyber knife: A painless and non-invasive treatment that delivers high doses of radiation to destroy tumors.
  • Deep Brain Stimulation: As a major way of decoding neural diseases, it is also used to treat those with involuntary muscle contractions and essential tremors.
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